Engrailed-2 promotes a malignant phenotype of esophageal squamous cell carcinoma through upregulating the expression of pro-oncogenic genes
Background A number of homeobox genes have been implicated in the development of various cancers.However, the role of engrailed 2 (EN2), a member of Bar Cabinet the homeobox gene superfamily, in esophageal squamous cell carcinoma (ESCC) remains unknown.Methods The expression of EN2 was examined using quantitative real-time PCR and immunohistochemis